Which condition is typically associated with mostly affecting males whose affected individuals have no affected parents?

The condition associated with predominantly affecting males and typically presenting in individuals with unaffected parents is primarily indicative of an X-linked recessive inheritance pattern. In this scenario, males inherit their single X chromosome from their mother, and if that X carries a recessive allele for a particular condition, the males will express the trait since they do not have a second X chromosome that could mask the effect of the recessive allele.

In X-linked recessive conditions, female carriers usually do not show symptoms because they have two X chromosomes and typically have one normal allele that compensates for the affected one. However, males who inherit the affected X chromosome will express the trait, and it is common for these males to have parents (the mother) who are carriers but not affected themselves. Thus, it aligns with the situation where affected individuals have no affected parents.

This mechanism distinguishes it from other types of inheritance patterns, such as autosomal dominant or autosomal recessive conditions, where the pattern of inheritance would typically show affected individuals having affected parents or a mass equal representation between sexes in the case of autosomal genes.