Which neurotransmitter is known for providing relief from pain and creating feelings of pleasure and well-being?

Endorphins are neuropeptides produced by the body that play a crucial role in the management of pain and the enhancement of feelings of pleasure and well-being. When the body experiences stress or pain, endorphins are released to help alleviate that pain, binding to the same receptors as opioids. This action creates a sense of euphoria and relaxation, often referred to as the "runner's high" experienced after prolonged exercise.

In this context, the focus on relief from pain specifically highlights endorphins’ well-documented function as natural painkillers. They help reduce the perception of pain and might contribute to feelings of satisfaction or happiness during and after stressful situations. This is why endorphins are often associated with rewarding feelings and mood elevation.

Other options like dopamine, acetylcholine, and GABA have their specific roles in the nervous system but do not directly serve the combined functions of pain relief and the elicitation of pleasure to the extent that endorphins do.